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Wisconsin Life Science History

Wisconsin Life Science Genealogy 2018 poster

Wisconsin Life Science Genealogy poster

The following includes select facts from life science history, both global and Wisconsin specific, that help explain the origins of the state's life science industry. We encourage you to learn about the scientists behind the discoveries, the entrepreneurs, philanthropists, political leaders, and significant events, institutions and companies that are the foundation of the life science industry in Wisconsin. If you are aware of a notable event, person, organization/company or accomplishment that we should include, please e-mail: Suggestions@InfoResource.org

We also invite you to explore Wisconsin Life Science Genealogy, a one-of-a-kind image that illustrates the founding technology origins of more than 120 life science firms located in the state. Specifically, the origins of the companies' founding technology with the state's universities and non-profit research organizations -- longstanding centers of innovation, technology transfer and job creation.

The newly updated Wisconsin and other state and province posters will be made available in high-resolution digital and printed formats for distribution throughout the U.S. and Canada in 2019. Information about sponsorship opportunities will soon be available.

Explore other state/province genealogy posters


1848 -- The University of Wisconsin was founded.

In 1848, Nelson Dewey, Wisconsin's first governor, signed the act that formally created the University of Wisconsin (UW) and its first class, with 17 students, met in a Madison school building on February 5, 1849.

From those beginnings, the university has grown into a large, diverse community, with about 40,000 students enrolled each year. UW-Madison is the oldest and largest campus in the University of Wisconsin System, a statewide network of 13 comprehensive universities.


1848 -- American Association for the Advancement of Science was founded.

American Association for the Advancement of Science American Association for the Advancement of Science founded in 1848 marked the emergence of a national scientific community in the United States, and was the first organization established to promote the development of science and engineering at the national level and to represent the interests of all its disciplines.

Today, the AAAS serves nearly 300 affiliated societies and academies of science and publishes the peer-reviewed general science journal Science. The non-profit AAAS is open to all and fulfills its mission to "advance science and serve society" through initiatives that include science policy, international programs, science education, and public understanding of science.


1859 -- Charles Darwin published "The Origin of Species."

Charles Darwin, 1855 In 1859, British naturalist Charles Darwin published "On the Origin of Species by Means of Natural Selection, or the Preservation of Favoured Races in the Struggle for Life" in which he postulated his theory of evolution that explained how the diverse of species on Earth evolved from a simple, singled-celled ancestor.

Darwin's theory of evolutionary selection holds that variation within species occurs randomly and that the survival or extinction of each organism is determined by that organism's ability to adapt to its environment. Darwin's theory of evolution remains the foundation of modern biology.



1865 -- Gregor Mendel, the father of modern genetics, presented his laws of heredity.

Gregor Mendel Gregor Mendel, an Augustinian considered the father of modern genetics, conducted crossbreeding experiments with pea plants between 1856 and 1863. Through this work, he established many of the rules of heredity.

"In 1859 I obtained a very fertile descendant with large, tasty seeds from a first generation hybrid. Since in the following year, its progeny retained the desirable characteristics and were uniform, the variety was cultivated in our vegetable garden, and many plants were raised every year up to 1865. (Gregor Mendel to Carl Nägeli, April 1867).



1887 -- Marine Hospital Service Hygienic Laboratory (National Institutes of Health) was founded.

Joseph Kinyoun The National Institutes of Health (NIH) traces its roots to 1887, when a one-room laboratory was created within the Marine Hospital Service (MHS), predecessor agency to the U.S. Public Health Service (PHS). The MHS was established in 1798 to provide for the medical care of merchant seamen -- charged by Congress with examining passengers on arriving ships for clinical signs of infectious diseases, such as cholera and yellow fever, to prevent epidemics.

During the 1870s and 1880s, scientists in Europe presented compelling evidence that microscopic organisms were the causes of several infectious diseases, and MHS officials closely followed these developments. In 1887, Joseph Kinyoun, a MHS physician trained in the new bacteriological methods, set up a one-room laboratory in the Marine Hospital at Stapleton, Staten Island, New York. Kinyoun called this facility a "laboratory of hygiene" in imitation of German facilities, and within a few months, he identified the cholera bacillus and used his Zeiss microscope to demonstrate it to his colleagues as confirmation of their clinical diagnoses (Photo: courtesy of the NIH Almanac).


1902 -- The Biologics Control Act was established.

Dr. Joseph J. Kinyoun, NIH The Biologics Control Act, established in 1902, had major consequences for the Hygienic Laboratory. It charged the laboratory with regulating the production of vaccines and antitoxins, making it a regulatory agency four years before passage of the 1906 Pure Food and Drugs Act. The danger posed by biological products that had emerged from bacteriologic discoveries resulted from their production in animals and their administration by injection. In 1901, thirteen children in St. Louis died after receiving diphtheria antitoxin contaminated with tetanus spores. This tragedy spurred Congress to pass the Biologics Control Act, and between 1903-1907 standards were established and licenses issued to pharmaceutical firms for making smallpox and rabies vaccines, diphtheria and tetanus antitoxins, and various other antibacterial antisera. (In 1972, responsibility for regulation of biologics was transferred to the Food and Drug Administration).

Marine Hospital Service seal The Marine Hospital Service (MHS), established in 1798, was reorganized in 1912 and renamed the Public Health Service (PHS). The PHS was authorized to conduct research into noncontagious diseases and into the pollution of streams and lakes in the U.S. During World War I, the PHS attended primarily to sanitation of areas around military bases in the U.S., and when the 1918 influenza pandemic struck Washington, physicians from the laboratory were pressed into service treating patients in the District of Columbia because so many local doctors had fallen ill.


1918 -- Spanish Influenza Pandemic.

Spanish Flu, 1918 It is estimated that between 25 and 40 million people died from the the influenza outbreak that began in 1918, swept across America in a week and around the world in three months. In all, between 500,000 and 700,000 Americans --civilians and soldiers-- died from the influenza, more than were lost in World War I, II, and the Korean and Viet Nam wars combined.

Additional information about the Spanish influenza pandemic, including audio interviews, photographs, teacher guides and more can be found through the The American Influenza Epidemic of 1918-1919: A Digital Encyclopedia, PBS's The American Experience, and Centers for Disease Control, National Vaccine Program Office.


1925 -- Wisconsin Alumni Research Foundation founded.

In 1925, the Wisconsin Alumni Research Foundation (WARF) was founded to manage a University of Wisconsin-Madison discovery that eventually eliminated the childhood disease rickets. UW-Madison biochemistry professor Harry Steenbock demonstrated the need for WARF's in 1923 when he proved that irradiation with ultraviolet light increased the vitamin D content of foods and other materials. Steenbock knew his invention held the potential to eliminate rickets, a crippling bone disease of children caused by vitamin D deficiency. He also knew that without proper management his discovery might never reach its full potential.

Thirty years earlier, a Steenbock's predecessor in the biochemistry department, Stephen Babcock, developed a novel test for determining the butter fat content of milk, but Babcock chose not to patent the discovery, instead giving it "freely to the world." Unfortunately, Babcock quickly learned that without patent protection he had no way to control the accuracy and reliability of the "Babcock tests" developed by companies. Determined not to repeat Babcock's experience, Steenbock filed a patent application with $300 of his own money, and was soon approached by the Quaker Oats Company which offered him nearly one-million dollars for the exclusive rights to his invention. However, rather than sell his discovery for his own profit, Steenbock strongly believed that any monetary gains resulting from his work should return to the UW-Madison to support scientific research, and Steenbock began making the rounds of UW-Madison administrators with his vision for a patent management agency that would protect discoveries made by UW-Madison faculty.

Steenbock idea caught the attention of Harry L. Russell, Dean of the College of Agriculture, and Charles Sumner Slichter, Dean of the Graduate School. Slichter subsequently solicited financial support from wealthy UW alumni in Chicago and New York, and received verbal pledges from a number of alumni, nine of whom would eventually contribute $100 each to fund the endeavor.

On May 8, 1925, Deans Slichter and Russell presented their plan for the agency before the executive committee of the UW Board of Regents proposing a non-profit patent organization independent of the university that would be funded initially by UW alumni and managed by a Board of Trustees composed of alumni. The primary purpose of the organization would be to manage patents on UW-Madison inventions such that net licensing revenues could be used to support further UW-Madison research. The UW Board of Regents officially sanctioned the plan on June 22, 1925 and the Wisconsin Alumni Research Foundation was born.

On February 19, 1927 WARF executed its first license agreement with the Quaker Oats Company which used Steenbock's irradiation process to fortify the vitamin D content of breakfast cereals. WARF subsequently licensed Steenbock's invention to a number of pharmaceutical companies for the development of a medicinal preparation of vitamin D called Viosterol. The foundation's efforts to advance Steenbock's discovery culminated in the vitamin D fortification of fluid milk. Thanks to the ready availability of vitamin D-enriched bread and milk, by the time Steenbock's patent expired in 1945 rickets had all but disappeared.

Over the years the foundation has developed a technology transfer model based upon partnership with the UW-Madison and industry, an approach that today makes it one of the most successful long-term benefactors of technological innovation and public welfare in the country. Since making its first grant of $1,200 in 1928, WARF has contributed more than $750 million dollars to the UW-Madison, including monies to fund research, build facilities, purchase lands and equipment, and support faculty and graduate student fellowships. WARF also holds equity positions in more than thirty spin-off companies across the U.S.


1930 -- The name of the Hygienic Laboratory was changed to the National Institute of Health.

Dr. Joseph J. Kinyoun, NIH In 1930, the Ransdell Act changed the name of the Hygienic Laboratory to the National Institute of Health (NIH) and authorized the establishment of fellowships for research into basic biological and medical problems. The roots of this act extended to 1918, when chemists who had worked with the Chemical Warfare Service in World War I sought to establish an institute in the private sector to apply fundamental knowledge in chemistry to problems of medicine.


1933 -- Thomas Hunt Morgan was awarded Nobel Prize in Physiology or Medicine for his chromosome theory of heredity.

Thomas Hunt Morgan Thomas Hunt Morgan pioneered the new science of genetics through experimental research with the fruit fly (Drosophila), laying the foundations for the future of biology. On the basis of fly-breeding experiments he demonstrated that genes are linked in a series on chromosomes and that they determine indentifiable, hereditary traits.

In 1928, Thomas Hunt Morgan transferred to the California Institute of Technology (Caltech) to organize work in biology, and five years later he was awarded the 1933 Nobel Prize in Physiology or Medicine for his chromosome theory of heredity. (Photo: © The Nobel Foundation)



1934 -- William Parry Murphy was awarded Nobel Prize in Medicine.

William Parry Murphy William Parry Murphy, a native of Stoughton, Wisconsin, shared the 1934 Nobel Prize for Medicine for discoveries concerning liver therapy in cases of anaemia.

In 1923 Murphy practised medicine and engaged in research on diabetes mellitus and on diseases of the blood. Murphy researched pernicious and other forms of anaemia. For the treatment of pernicious and hypochromic anaemia and for granulocytopenia he used intramuscular injections of extract of liver, and was associated with George Richards Minot and George Hoyt Whipple in work on pernicious anaemia and the treatment of it by means of a diet of uncooked liver. For this work he was awarded the Nobel Prize, together with Minot and Whipple.


1937 -- The National Cancer Institute was created.

National 
    Cancer Institue

In 1937, the National Cancer Institute (NCI) was created with sponsorship from every Senator in Congress, and was authorized to award grants to nonfederal scientists for research on cancer and to fund fellowships at NCI for young researchers.

Today, the NCI, part of the National Institutes of Health, is the federal government's principal agency for cancer research and training.


1944 -- Herbert Spencer Gasser was awarded Nobel Prize in Medicine.

Herbert S. Gasser Herbert S. Gasser, a native of Wisconsin and University of Wisconsin graduate (A.B. 1910, A.M. 1911), was awarded the 1944 Nobel Prize in Physiology or Medicine with Joseph Erlanger for their discoveries relating to the highly differentiated functions of single nerve fibres. (Photo: © The Nobel Foundation)

The first paper from Gasser on electrophysiology of the nerves dealt with action currents in the phrenic nerve. Later, the newly perfected low - voltage cathode - ray oscillograph was utilized in the work. Soon it was possible to demonstrate that the complexity of the oscillograph results was due to the different conductivity rates of different groups of nerve fibres. This work led to advances in our knowledge of the mechanism of pain and of reflex action and has inspired a large school of neurophysiologists.


1944 -- Public Health Service Act was established.

Warren Grant Magnuson Clinical Center The 1944 Public Health Service Act defined the shape of medical research in the post-war world. The entire NIH budget expanded from $8 million in 1947 to more than $1 billion in 1966, now fondly remembered as "the golden years" of NIH expansion. The 1944 PHS Act authorized NIH to conduct clinical research, and after the war Congress provided funding to build a research hospital, now called the Warren Grant Magnuson Clinical Center on the NIH campus in Bethesda, Maryland. The Center which opened in 1953 with 540 beds was designed to bring research laboratories into close proximity with hospital wards in order to promote productive collaboration between laboratory scientists and clinicians.

The NIH today, part of the U.S. Department of Health and Human Services, is the primary Federal agency for conducting and supporting medical research and is composed of 27 Institutes and Centers, providing leadership and financial support to researchers in every state and throughout the world.


1947 -- Transistor was invented at AT&T's Bell Laboratories.

John Bardeen William Shockley Walter Brattain The transistor, the invention that marked the dawn of the information age, was invented by John Bardeen, William Shockley and Walter Brattain at AT&T's Bell Laboratories. Bardeen, Shockley and Brattain were awarded the 1956 Nobel Prize in Physics for their discovery of the transistor effect.

Transistors have become an invisible technology that is part of almost every electronic device. Every major information age innovation was made possible by the transistor and its application can be found all around us.

Brattain received his B.S. degree from Whitman College in Walla Walla, WA and a M.A. degree from the University of Oregon. (Photos: © The Nobel Foundation)


1953 -- Double helix structure of DNA was revealed.

James D. Watson Francis Crick Maurice Wilkins The double helix structure of DNA, the hereditary molecule is revealed by two scientists, James D. Watson and Francis Crick. This is one of the key discoveries of the century. Watson and Crick shared the 1962 Nobel Prize for Physiology and Medicine with Maurice Wilkins for their discoveries concerning the molecular structure of nuclear acids and its significance for information transfer in living material.

Rosalind Franklin, whose work contributed to the discovery, died before this date and the rules do not allow a Nobel Prize to be awarded posthumously. (Photos: © The Nobel Foundation)


1958 -- Integrated circuit was invented.

Photo of Jack Kilby, inventor of the integrated circuit. Jack Kilby, an engineer at Texas Instruments shows only a transistor and other components on a slice of germanium. This invention (7/16-by-1/16-inches in size), called an integrated circuit, revolutionized the electronics industry. Kilby was awarded the 2000 Nobel Prize in Physics for his invention of the integrated circuit. (Photo: Jack Kilby courtesy of Texas Instruments)

Jack Kilby went on to pioneer military, industrial, and commercial applications of microchip technology. He headed teams that built both the first military system and the first computer incorporating integrated circuits. He later co-invented both the hand-held calculator and the thermal printer that was used in portable data terminals. Mr. Kilby officially retired from TI in 1983, but he maintained a significant involvement with the company throughout his life.


1958 -- Joshua Lederberg was awarded Nobel Prize in Medicine.

Joshua Lederberg Joshua Lederberg of the University of Wisconsin was awarded the 1958 Nobel Prize in Physiology or Medicine for his discoveries concerning genetic recombination and the organization of the genetic material of bacteria. (Photo: © The Nobel Foundation)

In 1947, Lederberg was appointed Assistant Professor of Genetics at the University of Wisconsin, where he was promoted to Associate Professor in 1950 and Professor in 1954. He organized the Department of Medical Genetics in 1957, amd was Chairman during 1957-1958.


1961 -- President John F. Kennedy expanded the U.S. Space Program

President John F. Kennedy expands U.S. Space Program Listen to President John F. Kennedy's speech in his historic message to a joint session of the Congress, on May 25, 1961 declared, "...I believe this nation should commit itself to achieving the goal, before this decade is out, of landing a man on the Moon and returning him safely to the Earth." This goal was achieved when astronaut Neil A. Armstrong became the first human to set foot upon the Moon at 10:56 p.m. EDT, July 20, 1969. Shown in the background are, (left) Vice President Lyndon Johnson, and (right) Speaker of the House Sam T. Rayburn. The expansion of the U.S. Space Program resulted in the development of a wide range of technology with enormous benefit to human and animal kind. (Photo: courtesy National Aeronautics & Space Administration)


1969 -- Man walked on the moon.

Neil Armstrong and Buzz Aldrin walk on the Moon. In July of 1969, Neil Armstrong and Buzz Aldrin, American astronauts, made history by becoming the first men to walk on the moon. Listen to Neil Armstrong's first words as he steps onto the lunar surface (66 kb .wav file). Photo: Courtesy of the National Aeronautics & Space Administration)

An important benefit of the Apollo Lunar Program and other NASA programs is the ever-growing pipeline of technology that improves human and veterinary healthcare diagnostics and therapeutics.


1969 -- Victor McKusick published "Mendelian Inheritance in Man".

Victor McKusick Victor McKusick, widely acknowledged as the father of medical genetics, spent his career studying the genetic basis of diseases and disorders with the belief that such an understanding could lead to new methods of diagnosis and treatment. He studied, identified, and mapped genes responsible for inherited conditions such as Marfan syndrome and dwarfism (specifically in Amish communities). In 1969, he proposed the idea of mapping the human genome, over 30 years before the Human Genome Project was established.

McKusick, a graduate of Johns Hopkins (M.D. 1946), spent his entire career there and founded the Division of Medical Genetics in 1957, the first research center and clinic of its kind. In 1969 he published the 1st edition of his book "Mendelian Inheritance of Man", one of the most comprehensive collections of inherited disease genes. In 2002, McKusick received the highest scientific honor in the U.S., the National Medal of Science.


1970 -- Earth Day prmoted by U.S. Senator Gaylord Anton Nelson.

Senator Gaylord Anton Nelson U.S. Senator Gaylord Nelson of Wisconsin helped promote an environmental teach-in or "Earth Day" to be held on April 22, 1970. More than 20 million people participated and it is now observed each year in more than 170 countries.

Gaylord Anton Nelson a Democrat from Clear Lake, Polk County, Wisconsin served in the State senate from 1948-56, (served as Democratic floor leader for four years), and Governor of Wisconsin from 1959-1962. Nelson served in the U.S. Senate from 1963-81. Nelson was subsequently counselor for the Wilderness Society, and was awarded the Presidential Medal of Freedom on September 29, 1995. (Photo: Gaylord Anton Nelson courtesy U.S. Senate Historical Office).


1971 -- NASDAQ Stock Market was founded.

NASDAQ Stock Market was founded as the world's first electronic stock market by the National Association of Securities Dealers. The NASDAQ system, created by the Bunker Ramos Corp. allowed the financial community, for the first time, to determine which market offered the best price on a given security.


1971 -- President Nixon declared war on cancer creating the Cancer Centers Program of the National Cancer Institute.

On Dec. 23, 1971, the National Cancer Act of 1971, enacted by President Richard Nixon as part of the nation’s war on cancer, established the Cancer Centers Program of the National Cancer Institute. The National Cancer Act, "The War on Cancer," gave the NCI unique autonomy at NIH with special budgetary authority. The annual budget of NCI, called the bypass budget, be submitted directly to the president, bypassing traditional approval by the NIH or the Department of HHS required of other NIH institutes.


1973 -- Recombinant DNA was perfected.

Stanley Cohen The modern era of biotechnology begins when Stanley Cohen of Stanford University and Herbert Boyer of the University of California at San Francisco successfully recombined ends of bacterial DNA after splicing a toad gene in between. They called their accomplishment recombinant DNA, but the media preferred the term genetic engineering. (Photo: Courtesy Stanley Cohen)

Boyer and Cohen's achievement was an advancement upon the techniques developed by Paul Berg, in 1972, for inserting viral DNA into bacterial DNA. Cohen's research at Stanford was with plasmids—the nonchromosomal, circular units of DNA found in, and exchanged by, bacteria, while Boyer's was restriction enzymes produced by bacteria to counter invasion by bacteriophages.


1974 -- Employee Retirement Income Security Act of 1974 (ERISA) was enacted.

Jacob Javits Pete Williams John N. Erlenborn, the ranking Republican on the House Committee, was responsible for bringing the Employee Retirement Income Security Act of 1974 (ERISA) to a floor vote, and is one of the ERISA’s "Founding Fathers." Together with Senator Jacob Javits (R-NY), Senator Pete Williams (D-NJ) and Congressman John Dent (D-PA), Erlenborn crafted provisions and participated in negotiations that were instrumental to the enactment of ERISA which was - and remains - the single most important legislation governing employee benefit plans in the United States creating a growing source of new capital. (Photos: Jacob Javits and Pete Williams courtesy U.S. Senate Historical Office).


1975 -- Monoclonal antibodies were produced.

Niels Jerne Georges Köhler César Milstein In 1975, Georges Köhler and César Milstein, showed how monoclonal antibodies can be generated by isolating individual fused myeloma cells.

The 1984 Nobel Laureate in Medicine was awarded jointly to: Niels Jerne, Georges Köhler and César Milstein for theories concerning the specificity in development and control of the immune system and the discovery of the principle for production of monoclonal antibodies. (Photos: © The Nobel Foundation).



1975 -- Howard Martin Temin was awarded the Nobel Prize in Medicine.

Howard Temin Howard Temin of the University of Wisconsin was awarded the 1975 Nobel Prize in Physiology or Medicine with David Baltimore and Renato Delbucco for their discoveries concerning the interaction between tumour viruses and the genetic material of the cell. (Photos: © The Nobel Foundation)

In 1960, Temin moved to Madison and became Assistant Professor in the McArdle Laboratory for Cancer Research, in the Medical School, at the University of Wisconsin-Madison. It was at the University of Wisconsin-Madison where Temin performed the experiments that led in 1964 to his formulating the DNA provirus hypothesis.


1976 -- Genentech was founded.

Genentech Genentech was founded by venture capitalist Robert Swanson and biochemist Dr. Herbert Boyer. In the early 1970s, Boyer and geneticist Stanley Cohen at Stanford University pioneered recombinant DNA technology.

Within a few short years Swanson and Boyer invented a new industry - biotechnology. In 1980, Genentech issued its Initial Public Offering (IPO) and raised $35 million with an offering that jumped from $35 a share to a high of $88 after less than an hour on the market. This event was one of the largest stock run-ups ever, and that event set the stage for future biotechnolgy industry offerings.


1977 -- First human gene was cloned.

Walter Gilbert Frederick Sanger Walter Gilbert induced bacteria to synthesize insulin and interferon, and Frederick Sanger published the complete sequence of phage FX174. The 1980 Nobel Laureate in Chemistry was awarded jointly to Frederick Sanger and Walter Gilbert for "for their contributions concerning the determination of base sequences in nucleic acids, and to Paul Berg for his fundamental studies of the biochemistry of nucleic acids, with particular regard to recombinant-DNA.

Gilbert and Sanger independently developed different methods to determine the exact sequence of the nucleotide building blocks in DNA. The investigations of Berg, Gilbert and Sanger have given us a detailed insight into the chemical basis of the genetic machinery in living organisms (Photos: © The Nobel Foundation).


1980 -- U.S. Supreme Court ruled man-made organism patentable.

Ananda Mohan Chakrabarty. Diamond v. Chakrabarty, the U.S. Supreme Court upholds five-to-four the patentability of genetically altered organisms, opening the door to greater patent protection for any modified life forms.

In 1972, Mohan Chakrabarty, a microbiologist, filed a patent application, assigned to the General Electric Co. for a human-made genetically engineered bacterium capable of breaking down multiple components of crude oil. Because of this property, which is possessed by no naturally occurring bacteria, Chakrabarty's invention was believed to have significant value for the treatment of oil spills. The application asserted 36 claims related to Chakrabarty's invention of "a bacterium from the genus Pseudomonas containing therein at least two stable energy-generating plasmids, each of said plasmids providing a separate hydrocarbon degradative pathway.

Opinions: Chief Justice Warren Burger delivered the opinion of the Court, in which justices Potter Stewart, Harry Blackmun, William Rehnquist, and John Paul Stevens joined. William Brennan filed a dissenting opinion, in which Byron White, Thurgood Marshall, and Lewis Powell joined.


1980 -- Bayh-Dole Act provided for university technology transfer.

Birch Bayh, Senator, Indiana Robert Dole, Senator, Kansas H.R.6933, Public Law: 96-517, December 12, 1980. A bill to amend title 35 of the United States Code. This Act known as the Bayh-Dole Act provided for the legal transfer of research and technology originating from U.S. universities and federal laboratories to private companies for commercialization. Technology transfer offices are now common in universities and federal laboratories and are the technology foundation for numerous biotechnology and medical device companies. (Photos: Birch Bayh and Robert Dole courtesy U.S. Senate Historical Office)


1983 -- The Orphan Drug Act was created.

U.S. FDA The Orphan Drug Act encouraged the research and development of drugs for rare or "orphan" diseases defined as a disease or condition that affects fewer than 200,000 Americans.

The Orphan Drug Act provided for financial incentives to help companies recover the cost of developing much needed therapies for small patient populations. The FDA estimates that more than 11 million patients in the U.S. and millions more around the world, have benefited from this legislation.


1984 -- Alec Jeffreys and technician Vicky Wilson discovered minisatellites leading to the development of genetic fingerprinting.

Sir Alec Jeffreys In 1984, geneticist Sir Alec Jeffreys, and technician Vicky Wilson at the University of Leicester in England discovered minisatellites leading to the development of genetic fingerprinting. The new technology was first used in 1985 to resolve a disputed immigration case that confirmed the identity of a British boy whose family was from Ghana.

In 1988, Colin Pitchfork was convicted of murdering two girls in 1983 and 1986 in Narborough, Leicestershire, England after his DNA samples matched semen samples taken from the two dead girls. Jeffreys' work in this case convicted the killer, but also exonerated Richard Buckland, a suspect who otherwise might have spent his life in prison. In 1994, Jeffreys' was knighted by Queen Elizabeth II for his services to genetics.


1990 -- Human Genome Project was established.

Human Genome Project Logo The U.S. Human Genome Project was established -- a 13-year effort coordinated by the U.S. Department of Energy and the National Institutes of Health. The main goals of the Human Genome Project were to provide a complete and accurate sequence of the 3 billion DNA base pairs that make up the human genome and to find all of the estimated 20,000 to 25,000 human genes. The project, originally planned to last 15 years, was expected to be completed by 2003 due to rapid technological advances.


1993 -- Biotechnology Industry Organization (BIO) was founded.

Biotechnology Industry Organization Biotechnology Industry Organization is the world's largest organization to serve and represent the biotechnology industry. BIO's leadership and service-oriented guidance have helped advance the industry and bring the benefits of biotechnology to people everywhere.



1993 -- Kary B. Mullis was awarded Nobel Prize in Chemistry.

Kary B. Mullis Kary B. Mullis of La Jolla, CA and a graduate of the University of California at Berkeley (Ph.D.) was awarded the 1993 Nobel Prize in Chemistry for contributions to the developments of methods within DNA-based chemistry, specifically for his invention of the polymerase chain reaction (PCR) method. (Photo: © The Nobel Foundation)

PCR allows scientists to quickly replicate small strands of DNA, greatly simplifying the sequencing and cloning of genes. First presented in 1985, PCR has become one of the most widespread methods of analyzing DNA. Notably, PCR requires the heat-stable enzyme Taq (Thermus Aquaticus) which originated from hot springs located in Yellowstone National Park.


1999 -- WiCell Research Institute was founded.

WiCell Research Institute In 1999, the WiCell Research Institute was founded as a non-profit organization to advance stem cell research. Prior to the company's founding, scientists had unsuccessfully tried to isolate and proliferate human embryonic stem cells. In 1998, University of Wisconsin researcher Dr. James Thomson successfully established and sustained several independent cell lines in culture.

The WiCell Research Institute provides human embryonic stem cells for research purposes to scientists all over the world and engages in basic research on stem cells and their application in prevalent cell-based diseases. Through the efforts of scientists like those at WiCell, diseases such as Parkinson's, diabetes, heart disease, and Alzheimer's may be treated by replacing damaged cells with healthy ones.


2001 -- Human Genome Project draft sequence was published.

Human Genome Project Logo The February 16 issue of Science and February 15 issue of Nature contained the working draft of the human genome sequence (U.S. Human Genome Project). Nature papers included initial analysis of the descriptions of the sequence generated by the publicly sponsored Human Genome Project, while Science publications focused on the draft sequence reported by the private company, Celera Genomics.


2001 -- Wisconsin Technology Council was founded.

In 2001, the Wisconsin Technology Council was founded as a non-profit organization by a bipartisan act of the state's governor and the Legislature. The Tech Council is the leading catalyst for the creation, development and retention of science and technology-based businesses in Wiconsin.


2007 -- The National Institutes of Health established the Human Microbiome Project.

Human Microbiome Project On Dec. 19, 2007, the Human Microbiome Project (HMP), a $150 million initiative, was established by the National Institutes of Health with the mission of generating resources that would enable the comprehensive characterization of the human microbiome and analysis of its role in human health and disease.

The HMP is the collection of all the microorganisms living in association with the human body, including eukaryotes, archaea, bacteria and viruses. Bacteria in an average human body number ten times more than human cells, for a total of about 1000 more genes than are present in the human genome.



Learn about the history of the life science industry in other states:

Plus the provinces of:

  • Alberta
  • British Columbia


Other Life Science History Resources

  • Albany Medical Center Prize in Medicine and Biomedical Research
  • American Association for the Advancement of Science
  • Chemical Heritage Foundation
  • Food & Drug Administration
  • Gotham Prize for Cancer Research
  • International Balzan Foundation
  • International Museum of Surgical Science
  • Lasker Foundation
  • National Academy of Sciences
  • National Health Museum
  • National Institutes of Health History, Office of
  • National Medal of Science
  • Prix Galien USA
  • The Nobel Foundation
  • The World Food Prize


If you are aware of a notable event or person at your company or organization that should be included in Wisconsin Life Science History, please e-mail us at: suggestions@inforesource.org.


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